A conjugate vaccine for typhoid
نویسندگان
چکیده
منابع مشابه
A conjugate vaccine against typhoid fever.
90 www.thelancet.com/infection Vol 14 February 2014 Zulfi qar Bhutta and colleages’ study in The Lancet Infectious Diseases marks an important milestone for the use of typhoid conjugate vaccines. Present Vi polysaccharide vaccines (Vi-PS) are not widely used because they cannot be given to children younger than 2 years and are thus excluded from the Expanded Programme of Immunization (EPI); fur...
متن کاملIndian Vi conjugate typhoid vaccine: misleading claims.
447 VOLUME 47__MAY 17, 2010 I refer to the article “Vi conjugate Typhoid Vaccine” written by Garg SP(1) on behalf of the manufacturer of Peda TyphTM in response to my previous article on the same subject(2). The author states that “this novel vaccine has been found to be safe and effective in inducing very high levels of immune response (>90%) in infants, young children and adults”, and goes fu...
متن کاملPhase I clinical trial of O-acetylated pectin conjugate, a plant polysaccharide based typhoid vaccine.
BACKGROUND Typhoid fever remains an important cause of morbidity and mortality in the developing countries. Vi capsular polysaccharide conjugate vaccine demonstrated safety and efficacy in young children in high endemic regions. A novel typhoid conjugate vaccine based on plant polysaccharide pectin was studied in a phase I trial. METHODS Fruit pectin, having the same carbohydrate backbone str...
متن کاملA forecast of typhoid conjugate vaccine introduction and demand in typhoid endemic low- and middle-income countries to support vaccine introduction policy and decisions
A Typhoid Conjugate Vaccine (TCV) is expected to acquire WHO prequalification soon, which will pave the way for its use in many low- and middle-income countries where typhoid fever is endemic. Thus it is critical to forecast future vaccine demand to ensure supply meets demand, and to facilitate vaccine policy and introduction planning. We forecasted introduction dates for countries based on spe...
متن کاملVaccine Treatment of Typhoid
the literature. Price, in the Lancet for December 1934, quotes the results of Uroiste of Montevideo and Stejskal of Vienna. These workers used carefully-standardized triple typhoid vaccine intravenously, to produce the shock. Triple vaccine, by virtue of its specificity, produces a more defined and uniform reaction than other foreign proteins or nonspecific vaccines. Being impressed by the succ...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2020
ISSN: 1078-8956,1546-170X
DOI: 10.1038/s41591-019-0743-5